The crash occurred around 4:15 a.m., when a 2008 Infiniti struck a 2004 Ford Explorer as it was turning left from Rt. 1 North onto S. Wood Ave., police said.
The drivers, a 25-year-old Elizabeth man and a 29-year-old Woodbridge woman, were taken to University Hospital in Newark with serious injuries.
Rt. 1 South was expected to be re-opened around 7 a.m., police said.
Anyone with information is urged to call Investigator Miesko Niedziolka at (908) 474-8505.
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